>> Something about having to grip the stylus makes my hand cramp up after a short period of time.
I notice that I have a much lighter grip when I’m just mousing around vs. when I’m writing or painting with the stylus. I think if I held the stylus like I hold a pen, I’d probably have the same issue, but I hold it with a very loose grip. So you might want to try that and see if it makes a difference.