I have seen it, but have not really found a fix for it. Things I have done that seem to have worked is to pull the mxf out of the structure that Canon has created. Also, I have a SAN shared solution that runs a bit slower than an internal raid on our Mac Pros. When I copy the files to the internal storage, they seem to work better as well. (I think I'm getting around 225 mb/s on the internal raid, and about 125 mb/s on the SAN.) I'm on the latest Lion, and latest versions of CS6. My clips are not typically long spans.
Working on a project with MXF files from a c300. they are long clips spanning across 2 or 2GB files and are causing issues in CS6 11.0.2 where frames are showing as green or black and freezing up or crashing AE or just being unusable.
One machine seems fine which is running ML. the 10.6.8 and 10.7.5 machines are having the issue.
not sure if there is any other major differentiator.