Many ways to go about this. How I would do it: do your modeling in C4D, use a simple contour toon shading texture, and then import the object into AE using the Element 3D plugin. Or you render the sequence out of C4D with normal shading and apply a toon filter effect in AE. It's faster, but may not look as good. You could even build the object entirely from extruded shapes within the AE 3d engine from scratch.
-TG